What are the signs of autophagy by ketosis? One of the first signs is fatigue and a reduced appetite. Anytime you follow a keto diet or do any type of intermittent fasting it will induce low blood sugar levels and the result of this is fatigue.

What are the signs of autophagy by ketosis? iStock-photo credit: hafakot
The reduced appetite comes from the change in levels of hormones like glucagon and insulin. Glucagon is a hormone that manages your blood sugar levels, and it has been shown to reduce your appetite. Also, as your insulin levels decreases your appetite decreases and this is why Type 2 diabetes drug like Ozempic is so popular with regards to suppressing your appetite and weight loss.
Another sign of autophagy by ketosis is having bad breath. If this happens it is a visible sign that your body has gone into ketosis. Autophagy plays an integral role in improved brain function. There was a 3-year study that linked intermittent fasting to improved brain function in older adults that had mild mental impairment.
Some studies show that the Keto diet can treat some neurodegenerative disorders such as Alzheimer’s disease. The Keto diet is not recommended for older adults, pregnant women, adolescents and people with eating disorders.
The Bottom Line is some of the signs of autophagy by ketosis is bad breath, reduced appetite and extreme fatigue.
If you have any interest in trying any of our Ethical Supplement products to help you heighten your immune system or assist you with your fitness, weight loss or health goals. You can get a discount below at this link.
About Author- Obi Obadike
References
- Yang H, Shan W, Zhu F, Wu J, Wang Q. Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms. Front Neurol. 2019 Jun 12;10:585. doi: 10.3389/fneur.2019.00585. PMID: 31244753; PMCID: PMC6581710.
- Jensen NJ, Wodschow HZ, Nilsson M, Rungby J. Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci. 2020 Nov 20;21(22):8767. doi: 10.3390/ijms21228767. PMID: 33233502; PMCID: PMC7699472.
- Ooi TC, Meramat A, Rajab NF, Shahar S, Ismail IS, Azam AA, Sharif R. Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study. Nutrients. 2020 Aug 30;12(9):2644. doi: 10.3390/nu12092644. PMID: 32872655; PMCID: PMC7551340.
- Tavernarakis N. Regulation and Roles of Autophagy in the Brain. Adv Exp Med Biol. 2020;1195:33. doi: 10.1007/978-3-030-32633-3_5. PMID: 32468455.
- Benito-Cuesta I, Diez H, Ordoñez L, Wandosell F. Assessment of Autophagy in Neurons and Brain Tissue. Cells. 2017 Aug 23;6(3):25. doi: 10.3390/cells6030025. PMID: 28832529; PMCID: PMC5617971.
- Shilpa J, Mohan V. Ketogenic diets: Boon or bane? Indian J Med Res. 2018 Sep;148(3):251-253. doi: 10.4103/ijmr.IJMR_1666_18. PMID: 30425213; PMCID: PMC6251269.
- Harvie M, Howell A. Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects-A Narrative Review of Human and Animal Evidence. Behav Sci (Basel). 2017 Jan 19;7(1):4. doi: 10.3390/bs7010004. PMID: 28106818; PMCID: PMC5371748.
- Finnell JS, Saul BC, Goldhamer AC, Myers TR. Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting. BMC Complement Altern Med. 2018 Feb 20;18(1):67. doi: 10.1186/s12906-018-2136-6. PMID: 29458369; PMCID: PMC5819235.
- Bostock ECS, Kirkby KC, Taylor BV, Hawrelak JA. Consumer Reports of “Keto Flu” Associated With the Ketogenic Diet. Front Nutr. 2020 Mar 13;7:20. doi: 10.3389/fnut.2020.00020. PMID: 32232045; PMCID: PMC7082414.
- Kanasaki K, Kawakita E, Koya D. Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon. Front Pharmacol. 2019 May 16;10:476. doi: 10.3389/fphar.2019.00476. PMID: 31156426; PMCID: PMC6531852.
- Al-Massadi O, Fernø J, Diéguez C, Nogueiras R, Quiñones M. Glucagon Control on Food Intake and Energy Balance. Int J Mol Sci. 2019 Aug 11;20(16):3905. doi: 10.3390/ijms20163905. PMID: 31405212; PMCID: PMC6719123.
- Scott RV, Bloom SR. Problem or solution: The strange story of glucagon. Peptides. 2018 Feb;100:36-41. doi: 10.1016/j.peptides.2017.11.013. PMID: 29412829; PMCID: PMC5805853.
- Camberos-Luna L, Gerónimo-Olvera C, Montiel T, Rincon-Heredia R, Massieu L. The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons. Neurochem Res. 2016 Mar;41(3):600-9. doi: 10.1007/s11064-015-1700-4. Epub 2015 Aug 25. PMID: 26303508.
- Liśkiewicz D, Liśkiewicz A, Grabowski M, Nowacka-Chmielewska MM, Jabłońska K, Wojakowska A, Marczak Ł, Barski JJ, Małecki A. Upregulation of hepatic autophagy under nutritional ketosis. J Nutr Biochem. 2021 Jul;93:108620. doi: 10.1016/j.jnutbio.2021.108620. Epub 2021 Mar 8. PMID: 33705944.


