Are Vitamin B12 shots good or bad?

Written by:

Obi Obadike

Obi Obadike

Celebrity Fitness & Nutrition Expert, CFT, SFN, M.S. Founder & CEO – Ethical Inc.
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Are Vitamin B12 shots good or bad? Vitamin B injections are considered safe as there are no major side effects to this. In some rare cases there can be an occasional allergic reaction or sensitivity to it. If you do experience any side effects, it is best to contact your doctor.

Are Vitamin B12 shots good or bad? Photo credit: iStock-GrafiThink

You would only need a Vitamin B injection if you don’t get enough Vitamin B through whole foods meaning through what you eat regularly. The daily recommended intake of Vitamin B-12 is 6 micrograms per day. The deficiency of B-12 is common among vegans and vegetarians because of their diet. And research studies show that 90% of people following these diets have a deficiency.

A Vitamin B injection always needs to be prescribed by a doctor and nobody else.  If you are low on Vitamin B-12 these are some of the symptoms, you can experience which is:

  • A decline in brain function and depression. There are studies that link deficiency in Vitamin B to depression.
  • A decline in bone density will put you at high risk of osteoporosis. There are studies that link reduced mass to Vitamin B12.
  • Vision loss can lead to age related macular degeneration.

Vitamin B-12 is found in animal foods and fortified foods. Here are some good food sources of Vitamin B-12 which is:

  • Liver
  • Canned Salmon
  • Milk
  • Eggs
  • Beef Kidney
  • Chicken
  • Ground Beef

There is some research that has shown that Vitamin B supplements are just as effective as Vitamin B injections.  Vegetarians and vegans are typically advised to take 10 mcg per day or 2000 mcg once per week.

The Bottom Line is if you eat a well-balanced healthy diet you don’t need to take Vitamin B injections or Vitamin B supplements. If you are vegan and vegetarian, you will most likely be deficient in Vitamin B and you would you need to take an additional supplement to counteract that.

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  1. Kwong JC, Carr D, Dhalla IA, Tom-Kun D, Upshur RE. Oral vitamin B12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectives. BMC Fam Pract. 2005 Feb 21;6(1):8. doi: 10.1186/1471-2296-6-8. PMID: 15723708; PMCID: PMC554115.
  2. Masucci L, Goeree R. Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis. Ont Health Technol Assess Ser. 2013 Nov 1;13(24):1-24. PMID: 24379898; PMCID: PMC3874775.
  3. Kolber MR, Houle SK. Oral vitamin B12: a cost-effective alternative. Can Fam Physician. 2014 Feb;60(2):111-2. PMID: 24522672; PMCID: PMC3922551.
  4. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PMID: 25117994.
  5. James J, Warin RP. Sensitivity to cyanocobalamin and hydroxocobalamin. Br Med J. 1971 May 1;2(5756):262. doi: 10.1136/bmj.2.5756.262. PMID: 5572387; PMCID: PMC1796408.
  6. Bilwani F, Adil SN, Sheikh U, Humera A, Khurshid M. Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report. J Pak Med Assoc. 2005 May;55(5):217-9. PMID: 15960291.
  7. Melton ME, Kochman ML. Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia. Metabolism. 1994 Apr;43(4):468-9. doi: 10.1016/0026-0495(94)90078-7. PMID: 8159105.
  8. Ebesunun MO, Umahoin KO, Alonge TO, Adebusoye LA. Plasma homocysteine, B vitamins and bone mineral density in osteoporosis: a possible risk for bone fracture. Afr J Med Med Sci. 2014 Mar;43(1):41-7. PMID: 25335377.
  9. Ruan J, Gong X, Kong J, Wang H, Zheng X, Chen T. Effect of B vitamin (folate, B6, and B12) supplementation on osteoporotic fracture and bone turnover markers: a meta-analysis. Med Sci Monit. 2015 Mar 24;21:875-81. doi: 10.12659/MSM.893310. PMID: 25805360; PMCID: PMC4384513.
  10. Dangour AD, Allen E, Clarke R, Elbourne D, Fletcher AE, Letley L, Richards M, Whyte K, Uauy R, Mills K. Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial. Am J Clin Nutr. 2015 Sep;102(3):639-47. doi: 10.3945/ajcn.115.110775. Epub 2015 Jul 1. PMID: 26135351; PMCID: PMC4548176.
  11. Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM, Schneede J, Blom HJ, Hoefnagels WH, van Staveren WA. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr. 2006 Aug;84(2):361-70. doi: 10.1093/ajcn/84.1.361. PMID: 16895884.
  12. Sun Y, Lu CJ, Chien KL, Chen ST, Chen RC. Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer’s disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin Ther. 2007 Oct;29(10):2204-14. doi: 10.1016/j.clinthera.2007.10.012. PMID: 18042476.
  13. Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B(12) deficiency among vegetarians? Nutr Rev. 2013 Feb;71(2):110-7. doi: 10.1111/nure.12001. Epub 2013 Jan 2. PMID: 23356638.
  14. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. Eur J Clin Nutr. 2014 May;68(5):541-8. doi: 10.1038/ejcn.2014.46. Epub 2014 Mar 26. Erratum in: Eur J Clin Nutr. 2016 Jul;70(7):866. PMID: 24667752.
  15. Andrès E, Federici L, Affenberger S, Vidal-Alaball J, Loukili NH, Zimmer J, Kaltenbach G. B12 deficiency: a look beyond pernicious anemia. J Fam Pract. 2007 Jul;56(7):537-42. PMID: 17605945.
  16. Carmel R. Malabsorption of food cobalamin. Baillieres Clin Haematol. 1995 Sep;8(3):639-55. doi: 10.1016/s0950-3536(05)80224-0. PMID: 8534965.
  17. Oral or intramuscular vitamin B12? Drug Ther Bull. 2009 Feb;47(2):19-21. doi: 10.1136/dtb.2009.01.0002. Erratum in: Drug Ther Bull. 2009 Apr;47(4):48. PMID: 19193702.

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