Mounjaro vs Ozempic- What’s the difference? Mounjaro is an FDA approved drug that helps to regulate Type 2 diabetes. It is a once a week injection that helps to control your blood sugar levels. It is approved for treating Type 2 diabetes.
What is interesting is the FDA has also approved this as a treatment for Type 2 diabetes but not weight loss yet. There have been research studies that have shown that Mounjaro has helped reduce blood pressure levels, reduced the risk of a heart attack and stroke.

Mounjaro vs Ozempic- What’s the difference? iStock-photo credit: Douglas Cliff
Ozempic is also an approved FDA medication for adults with Type 2 diabetes. This also helps control blood sugar levels with all types of people that have Type 2 diabetes. One of the side effects of Ozempic is weight loss and it has been very popular in the health community.
A 68-week research study published in the New England Journal of Medicine shown that the participants who received once a week injections lost 15% reduction in bodyweight and had less risks of heart disease.
Some of the similarities between Mounjaro vs Ozempic.
- Both drugs can help control blood sugar levels in people that have Type 2 diabetes.
- Helps promote weight loss and obesity.
- Reduces the risk of heart attack and stroke.
- The side effects of both drugs are vomiting, diarrhea, constipation, nausea, etc.
Differences between Mounjaro vs Ozempic
The main difference is how each drug works biologically in the body. Mounjaro is a dual acting glucose independent insulinotropic polypeptide. But Ozempic is only a GLP-1 receptor agonist. Another difference is that Ozempic is a drug that is FDA approved for people that have Type 2 diabetes and cardiovascular heart disease. But Mounjaro is currently not approved for that use.
When it comes to cost Mounjaro is more expensive than Ozempic. Mounjaro costs about $1,023 a month without insurance and Ozempic costs about $936 a month.
Both Mounjaro and Ozempic are effective in reducing blood sugar levels and helping weight loss.
The Bottom Line the main differences between Ozempic and Mounjaro are the costs because Mounjaro is more expensive than Ozempic. And the other difference is that Ozempic is FDA approved for people that have Type 2 Diabetes and cardiovascular diseases, but Mounjaro isn’t.
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About Author- Obi Obadike
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References
- Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038
- Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989-1002. doi:10.1056/NEJMoa2032183
- Frías JP, Davies MJ, Rosenstock J, et al. Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. N Engl J Med. 2021;385(6):503-515. doi:10.1056/NEJMoa2107519
- Peterson-KFF Health System Tracker. How do prices of drugs for weight loss in the U.S. compare to peer nations prices?


