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What Are The Side Effects of Sucralose?

Written by:

Obi Obadike

Obi Obadike

Celebrity Fitness & Nutrition Expert, CFT, SFN, M.S. Founder & CEO – Ethical Inc.
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What are the side effects of sucralose? Some of the side effects is that it raises the blood sugar levels and insulin levels in people who don’t consume artificial sweeteners regularly. There was a small study done on 17 people who had severe obesity who didn’t consume sucralose regularly.

The results of this study showed that sucralose increased the blood sugar levels by 14% and the insulin levels by 20%. The analysis of this study is that sucralose can raise blood sugar levels and insulin levels in people who don’t consume sucralose regularly.

What are the side effects of sucralose? Istock- HT Ganzo

Sucralose is marketed as splenda as an artificial sweetener that comes from a yellow package. It is sweeter than regular sugar with 0 calories which is one of the appeals to most people.

It is common to find sucralose in foods and drinks such as ice cream, candy, yogurt, and soda. Foods and beverages that have sucralose may increase appetite making you eat more food. There still needs to be more research to 100% validate this.

There are studies that have shown that sucralose can change your gut microbiome by reducing the number of beneficial bacteria in your body by half. There has been research that were done on animals that showed that sucralose can increase inflammation in the body. Most of the research studies were done on rodents and more research needs to be done on humans in terms of the effects of sucralose.

Sucralose can be found in:

  • Ready-made meals
  • Desserts
  • Cakes
  • Toothpaste
  • Packaged foods
  • Chewing gum

Sucralose is an approved ingredient across the world and studies in the U.S (United States) and (United Kingdom) UK have found artificial sweeteners like Splenda doesn’t cause cancer. Sucralose is considered to be safe by the FDA, (Food and Drug Administration). Consuming artificial sweeteners is ok if it is in minimal amounts.

One of the appealing things about using sucralose as an artificial sweetener over regular sugar is the lower calorie content. That appeals to a lot of people, and it can help with weight loss because sucralose has minimal calories.

The Bottom Line is consumption of sucralose is safe to take as long as you consume it in moderation. There is no clear scientific evidence that it is harmful to human beings.

If you have any interest in trying any of our Ethical Supplement  products to help you heighten your immune system or assist you with your fitness, weight loss or health goals. You can go to https://ethicalinc.com/product/appetite-suppressant/

References

  1. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29. doi: 10.1080/15287390802328630. PMID: 18800291.
  2. West CE, Renz H, Jenmalm MC, Kozyrskyj AL, Allen KJ, Vuillermin P, Prescott SL; in-FLAME Microbiome Interest Group. The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies. J Allergy Clin Immunol. 2015 Jan;135(1):3-13; quiz 14. doi: 10.1016/j.jaci.2014.11.012. PMID: 25567038.
  3. Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035. PMID: 22424233; PMCID: PMC5050011.
  4. Pepino MY, Tiemann CD, Patterson BW, Wice BM, Klein S. Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care. 2013 Sep;36(9):2530-5. doi: 10.2337/dc12-2221. Epub 2013 Apr 30. PMID: 23633524; PMCID: PMC3747933.
  5. Ma J, Bellon M, Wishart JM, Young R, Blackshaw LA, Jones KL, Horowitz M, Rayner CK. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G735-9. doi: 10.1152/ajpgi.90708.2008. Epub 2009 Feb 12. PMID: 19221011; PMCID: PMC2670679.
  6. Ma J, Chang J, Checklin HL, Young RL, Jones KL, Horowitz M, Rayner CK. Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects. Br J Nutr. 2010 Sep;104(6):803-6. doi: 10.1017/S0007114510001327. Epub 2010 Apr 27. PMID: 20420761.
  7. Ford HE, Peters V, Martin NM, Sleeth ML, Ghatei MA, Frost GS, Bloom SR. Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects. Eur J Clin Nutr. 2011 Apr;65(4):508-13. doi: 10.1038/ejcn.2010.291. Epub 2011 Jan 19. PMID: 21245879.
  8. Horne J, Lawless HT, Speirs W, Sposato D. Bitter taste of saccharin and acesulfame-K. Chem Senses. 2002 Jan;27(1):31-8. doi: 10.1093/chemse/27.1.31. PMID: 11751465.
  9. Schiffman SS, Rother KI. Sucralose, a synthetic organochlorine sweetener: overview of biological issues. J Toxicol Environ Health B Crit Rev. 2013;16(7):399-451. doi: 10.1080/10937404.2013.842523. PMID: 24219506; PMCID: PMC3856475.
  10. de Oliveira DN, de Menezes M, Catharino RR. Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts. Sci Rep. 2015 Apr 15;5:9598. doi: 10.1038/srep09598. PMID: 25873245; PMCID: PMC4397539.

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